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Institute for Clinical Neurobiology Wuerzburg

Contact information:

Prof. Dr. Michael Sendtner
Institute for Clinical Neurobiology
Versbacher Strasse 5
97078 Würzburg
Germany
Tel. +49 (0)931-201-44000
Fax +49 (0)931-201-44009
E-Mail: Sendtner_M@klinik.uni-wuerzburg.de

ALS Clinic:

The Institute for Clinical Neurobiology is also involved in the patient care of the special care centre for motoneuron diseases (Dept. of Neurology, Director Prof. Volkmann), in order to ensure the transfer of basic science into clinical applications.

Research Lines:

Central research focus are studies on the mechanisms of neuronal cell death, the establishment and analysis of animal models for motoneuron diseases, and development of therapeutic strategies for the treatment of amyotrophic laterals sclerosis and spinal muscular atrophy.
Further lines of research focus on the mechanisms how neural stem cells differentiate into neurons and functional neural circuits. Investigation of the signal transduction pathways by which neurotrophic factors influence differentiation, survival and axonal growth of neurons are of central interest. The generation and analysis of gene knockout mice allows investigating which signal molecules are involved in mediating such essential cellular effects of neurotrophic factors.

Another research focus is the analysis of the pathophysiology of spinal muscular atrophy, the most common form of motoneuron disease in children. This disease is characterized by axonal defects and defects of neurotransmission at neuromuscular synapses. These defects are due to reduced ï¢-actin mRNA transport in axons of motoneurons, resulting in functional deficits in the presynaptic parts of neuromuscular endplates. This finding in isolated motoneurons and in animal models for spinal muscular atrophy correlates with clinical observations in patients with spinal muscular atrophy. On the basis of these experiments, new therapeutic strategies for this disease can now be developed.

Central technologies, beside the generation of mouse models are modern microscopic techniques, including confocal microscopy, 2-photone microscopy and life imaging, in order to study defects in structure and function in neurons from models of neurodegenerative diseases.

Top 10 Publications:

  1. Simon CM, Jablonka S, Ruiz R, Tabares L, Sendtner M. Ciliary neurotrophic factor-induced sprouting preserves motor function in a mouse model of mild spinal muscular atrophy. Dec 18. [Epub ahead of print. Hum Mol Genet. 2009
  2. Wiese, S., Herrmann, T., Drepper, C., Jablonka, S., Funk, N., Klausmeyer, A., Rogers, M.L., Rush, R. and M Sendtner. Isolation and enrichment of embryonic mouse motoneurons from the lumbar spinal cord of individual mouse embryos . Nature Protocols 5, 31-28, 2009
  3. Drepper, C., Herrmann, T., Wessig, C., Beck, M. and Sendtner M. C-terminal FUS/TLS mutations in familial and sporadic ALS in Germany. Neurobiol Aging. Dec 15, Epub ahead of print, 2009
  4. Trimbuch, T., Beed, P., Vogt, J., Schuchmann, S., Maier, N., Kintscher, M., Breustedt, J., Schuelke, M., Streu, N., Kieselmann, O., Brunk, I., Laube, G., Strauss, U., Battefeld, A., Wende, H., Birchmeier, C., Wiese, S., Sendtner, M., Kawabe, H., Kishimoto-Suga, M., Brose, N., Baumgart, J., Geist, B., Aoki, J., Savaskan, N.E., Bräuer. A.U., Chun, J., Ninnemann, O., Schmitz, D. and R. Nitsch. Synaptic PRG-1 modulates excitatory transmission via lipid phosphate-mediated signaling. Cell 138,1222-35, 2009
  5. Fischer, M., Marques Pereira, P., Holtmann, B., Simon, C.M., Hanauer, A., Heisenberg, M. and Sendtner M. P90 Ribosomal s6 kinase 2 negatively regulates axon growth in motoneurons. Mol. Cell. Neurosci. 42, 134-41, 2009
  6. Fischer, M., Raabe, T., Heisenberg, M. and M. Sendtner. Drosophila RSK negatively regulates Bouton Number at the Neuromuscular Junction. Dev. Neurobiol. 69, 212-220, 2009
  7. Wiese, S., Jablonka, S., Holtmann, B., Orel, N., Rajagopal, R., Chao, M.V., Sendtner, M. Adenosine receptor A2A-R contributes to motoneuron survival by transactivating the tyrosine kinase receptor TrkB. PNAS 104, 17210-17215, 2007
  8. Ito, Y., Wiese, S., Schweizer, U., Chittka, A., Rossoll, W., Bömmel, H., Watabe, K., Wegner, M. and M. Sendtner. The Role of Krox20 and Sox10 in Regulation of Ciliary Neurotrophic Factor (Cntf) Gene Expression in Schwann Cells. PNAS 16, 7871-7876, 2006
  9. Götz, R., Wiese, S., Takayama, S., Camarero, G.C., Rossoll, W., Schweizer, U., Troppmair, J., Jablonka, S., Holtmann, B., Reed, J.C., Rapp, U.R. and M. Sendtner. Essential role of bag-1 for differentiation and survival of neural precursor cells. Nat. Neurosci. 8, 1169-1178, 2005
  10. Sendtner, M. Mouse mutants and cell culture models of motoneuron disease. Drug Discovery Today 1, 345-350, 2004